A recent massive collaborative study published in the Proceedings of the National Academy of Sciences found that mice were extremely poor models to use for studying causes of and testing treatments for human inflammatory conditions. Now Independent Science News has published a very interesting and concerning overview and analysis of some of the problems with animal testing, especially for modelling effectiveness of drugs or modelling the safety of chemicals in food and environmental toxins:
The results of these experiments challenge the longstanding scientific presumption holding that animal experiments are of direct relevance to humans. For that reason they potentially invalidate the entire body of safety information that has been built up to distinguish safe chemicals from unsafe ones. The new results arise from basic medical research, which itself rests heavily on the idea that treatments can be developed in animals and transferred to humans.